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Listar por autor "García Heredia, José Manuel"
Mostrando ítems 1-20 de 25
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Ponencia
A Feature Selection and Association Rule Approach to Identify Genes Associated with Metastasis and Low Survival in Sarcoma
Linares Barrera, María Lourdes; Martínez Ballesteros, María del Mar; García Heredia, José Manuel; Riquelme Santos, José Cristóbal (SpringerLink, 2023-08)Sarcomas are rare mesodermal tumors of heterogeneous nature and have a higher incidence in children. The relative 5-year ...
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Artículo
A new treatment for sarcoma extracted from combination of miRNA deregulation and gene association rules
García Heredia, José Manuel; Perez, Marco; Verdugo Sivianes, Eva María; Martínez Ballesteros, María del Mar; Ortega Campos, Sara M.; Carnero, Amancio (Springer Nature, 2023) -
Tesis Doctoral
Análisis comparado en animales y plantas de la función del citocromo c respiratorio en el proceso de muerte celular programada
García Heredia, José Manuel (2008-06-13) -
Artículo
Autoencoded DNA methylation data to predict breast cancer recurrence: Machine learning models and gene-weight significance
Macías García, Laura; Martínez Ballesteros, María del Mar; Luna Romera, José María; García Heredia, José Manuel; García Gutiérrez, Jorge; Riquelme Santos, José Cristóbal (Elsevier, 2020)Breast cancer is the most frequent cancer in women and the second most frequent overall after lung cancer. Although the ...
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Artículo
Breast tumor cells promotes the horizontal propagation of EMT, stemness, and metastasis by transferring the MAP17 protein between subsets of neoplastic cells
García Heredia, José Manuel; Otero Albiol, Daniel; Pérez, Marco; Pérez Castejón, Elena; Muñoz Galván, Sandra; Carnero, Amancio (Springer Nature, 2020)MAP17 (PDZK1IP1) is a small protein regulating inflammation and tumor progression, upregulated in a broad range of carcinomas. ...
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Patente. Invención
Construcción génica que codifica para el citocromo c y procedimiento de obtención
Rosa Acosta, Miguel Ángel de la; Cerda Haynes, Berta de la; Molina Heredia, Fernando Publio; Rodríguez Roldán, Vicente; Hervás Morón, Manuel; García Heredia, José Manuel; Navarro Carruesco, José Antonio (Oficina Española de Patentes y Marcas (OEPM), 2009-12-16)Construcción génica que codifica para el citocromo c y procedimiento de obtención. Se describe una construcción génica ...
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Artículo
Coordinated downregulation of Spinophilin and the catalytic subunits of PP1, PPP1CA/B/C, contributes to a worse prognosis in lung cancer
Verdugo Sivianes, Eva María; Navas, Lola; Molina Pinelo, Sonia; Quintanal Villalonga, Álvaro Diego; García Heredia, José Manuel; Felipe Abrio, Blanca; Muñoz Galván, Sandra (Impact Journals, 2017)The scaffold protein Spinophilin (Spinophilin, PPP1R9B) is one of the regulatory subunits of phosphatase-1 (PP1), directing ...
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Artículo
Cytochrome c signalosome in mitochondria
Díaz Moreno, Irene; García Heredia, José Manuel; Díaz Quintana, Antonio Jesús; Rosa Acosta, Miguel Ángel de la (Springer, 2011)Cytochrome c delicately tilts the balance between cell life (respiration) and cell death (apoptosis). Whereas cell life ...
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Artículo
Decoding Warburg's hypothesis: tumor-related mutations in the mitochondrial respiratory chain
García Heredia, José Manuel; Carnero Moya, Amancio (Impact Journals, 2015)Otto Warburg observed that cancer cells derived their energy from aerobic glycolysis by converting glucose to lactate. ...
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Ponencia
Discovery of Genes Implied in Cancer by Genetic Algorithms and Association Rules
Sánchez Medina, Alejandro; Gil Pichardo, Alberto; García Heredia, José Manuel; Martínez Ballesteros, María del Mar (Springer, 2016)This work proposes a methodology to identify genes highly related with cancer. In particular, a multi-objective evolutionary ...
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Artículo
Dr. Jekyll and Mr. Hyde: MAP17’s up-regulation, a crosspoint in cancer and inflammatory diseases
García Heredia, José Manuel; Carnero Moya, Amancio (BioMed Central, 2018)Inflammation is a common defensive response that is activated after different harmful stimuli. This chronic, or ...
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Artículo
Efficacy of bortezomib in sarcomas with high levels of MAP17 (PDZK1IP1
Pérez, Marco; Peinado Serrano, Javier; García Heredia, José Manuel; Felipe Abrio, Irene; Tous Rivera, Cristina; Ferrer, Irene; Martín Broto, Javier (Impact Journals, 2016)Sarcomas are malignant tumors accounting for a high percentage of cancer morbidity and mortality in children and young ...
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Artículo
Machine learning techniques to discover genes with potential prognosis role in Alzheimer’s disease using different biological sources
Martínez Ballesteros, María del Mar; García Heredia, José Manuel; Nepomuceno Chamorro, Isabel de los Ángeles; Riquelme Santos, José Cristóbal (Elsevier, 2017)Alzheimer’s disease is a complex progressive neurodegenerative brain disorder, being its prevalence ex pected to rise over ...
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Artículo
MAP17 predicts sensitivity to platinum-based therapy, EGFR inhibitors and the proteasome inhibitor bortezomib in lung adenocarcinoma
Ferrer, Irene; Quintanal Villalonga, Álvaro Diego; Molina Pinelo, Sonia; García Heredia, José Manuel; Pérez, Marco; Carnero Moya, Amancio (BMC, 2018)Background The high incidence and mortality of lung tumours is a major health problem. Therefore, the identification both ...
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Artículo
New markers for human ovarian cancer that link platinum resistance to the cancer stem cell phenotype and define new therapeutic combinations and diagnostic tools
Muñoz Galván, Sandra; Felipe Abrio, Blanca; García Carrasco, Miguel; Domínguez Piñol, Julia; Suarez Martínez, Elisa; Verdugo Sivianes, Eva María; Espinosa Sánchez, Asunción; Navas Maldonado, Lola Eufemia; Otero Abiol, Daniel; García Heredia, José Manuel; Carnero Moya, Amancio (BMC, 2019)BACKGROUND: Ovarian cancer is the leading cause of gynecologic cancer-related death, due in part to a late diagnosis and ...
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Artículo
Nitration of tyrosine 74 prevents human cytochrome c to play a key role in apoptosis signaling by blocking caspase-9 activation
García Heredia, José Manuel; Díaz Moreno, Irene; Nieto Mesa, Pedro Manuel; Orzáez, Mar; Kocanis, Stella; Teixeira, Miguel; Pérez Payá, Enrique; Díaz Quintana, Antonio Jesús; Rosa Acosta, Miguel Ángel de la (Elsevier, 2010)Tyrosine nitration is one of the most common post-transcriptional modifications of proteins, so affecting their structure ...
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Artículo
NUMB and NUMBL differences in gene regulation
García Heredia, José Manuel; Carnero Moya, Amancio (Impact Journals, 2018)NUMB, and its close homologue NUMBL, behave as tumor suppressor genes by regulating the Notch pathway. The downregulation ...
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Artículo
Numb-like (NumbL) downregulation increases tumorigenicity, cancer stem cell-like properties and resistance to chemotherapy
García Heredia, José Manuel; Verdugo Sivianes, Eva María; Lucena Cacace, Antonio; Molina Pinelo, Sonia; Carnero Moya, Amancio (Impact Journals, 2016)NumbL, or Numb-like, is a close homologue of Numb, and is part of an evolutionary conserved protein family implicated in ...
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Artículo
PAI1 is a Marker of Bad Prognosis in Rectal Cancer but Predicts a Better Response to Treatment with PIM Inhibitor AZD1208
Muñoz Galván, Sandra; Rivero, María; Peinado Serrano, Javier; Martinez Pérez, Julia; Fernández Fernández, María del Carmen; Ortiz, María José; García Heredia, José Manuel; Carnero Moya, Amancio (MDPI, 2020)Colorectal cancer (CRC) is the third most common cancer worldwide. The standard treatment in locally advanced rectal cancer ...
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Artículo
Role of Mitochondria in Cancer Stem Cell Resistance
García Heredia, José Manuel; Carnero Moya, Amancio (Multidisciplinary Digital Publishing Institute (MDPI), 2020)Cancer stem cells (CSC) are associated with the mechanisms of chemoresistance to different cytotoxic drugs or radiotherapy, ...